Introduction

SCBA-SinoBiological Young Investigator Awards are co-sponsored by the Seattle Chinese Biomedical Association (SCBA) and Sino Biological (Biotechnology company).

SCBA (http://scbahome.org/) is a volunteer run non-profit 501(C)(3) organization founded in 1993 in Seattle. SCBA strives to provide a forum for the exchange of information related to life sciences and the Chinese community in the great Seattle area.

Sino Biological (https://www.sinobiological.com/) is an internationally recognized reagent supplier and service provider specialized in recombinant protein production and antibody development. The company’s ever-growing portfolio of products includes recombinant proteins, monoclonal antibodies, ELISA assay kits, expression clones, cell culture media, and other molecular biology tools.

SCBA-SinoBiological Young Investigator Awards are established to recognize early-career SCBA members in Washington State who have made significant contributions to their respective biomedical research fields. The Awards also value individuals who are committed to making contributions to the SCBA seminars and/or annual meetings.

This year we only accept self-nominations, which means all applicants need to complete an online application process before the indicated deadline. Review processes will take place every year prior to the SCBA annual meeting. Awardees will be invited to present their research in one of SCBA regular seminars or annual meeting either online or in person.

Eligibility Requirements

1) The applicants must be young investigators in their early career as a student pursuing a terminal degree, a postdoctoral fellow, a non-tenured assistant professor within 5 years of starting the faculty position, or a PhD scientist in industry with less than 5 years of experience.

2) The applicant has made significant contribution to their biomedical research field or demonstrated great potential as a graduate student.

3) The applicant is a current SCBA member.

4) The applicant is currently studying or working in Washington State.

Application Procedure

1) Fill out the online form, which includes several short-response questions or essays.

2) Upload a short description of your research and contribution to the field in PDF. This document should be no more than 1 page (plus references if applicable) (font size 11 point or larger, 1’’ or more margin). The document should be in English. Please do not include any proprietary information.

3) Upload your resume/CV or NIH BioSketch in PDF.

4) One recommendation letter is desired but not required. The letter can either be sent directly to scbaaward@gmail.com (with award type and applicant name in subject line) or uploaded along with the application.

5) Please submit your application no later than August 31st, 2022.

Review Process

All applications will be reviewed by a professional review panel consists of experts from both academia and industry. Each application will be scored by all reviewers and ranked, and top candidates will be selected for awards.

Award types, Announcement, and Presentation

Depending on the applicant pool, there will be 1-2 awards in each of the four categories (student, postdoc, industrial scientist and junior faculty). The number of awards in each category will be ultimately determined by the number and credential of respective applicants. Each award will consist of a plaque and an honorarium of $500. The awards will be announced prior to SCBA annual meetings (Oct-Dec). Awardees will be invited to give a presentation of their work in SCBA seminars or annul meetings.

While we are planning to return to in-person activities in 2022, we are monitoring the ongoing COVID-19 pandemic and assessing the safest way for our members and applicants. We will post updates for seminars, annual meetings, and other events on our website.

For any questions, please send email to scbaaward@gmail.com.

APPLY HERE!

西雅图华人生物医学协会SCBA今晚学术活动通知

时间：2022 年6月25 日（星期六）晚上6点到8点（美国太平洋时间夏时制）
（北京时间星期天上午9点到11点）
地点：网络会议        会议室：941 1246 3815        密码：SCBA
会议链接：https://zoom.us/j/94112463815
1. SARS-CoV-2 感染和疫苗引发的免疫反应：经验教训和前景
演讲人：刘善虑博士
2. 突发公共卫生事件实验室应急能力建设
演讲人：陈唯军博士
详情请见附件中文海报 (SCBA Academic Seminar on June 25th 2022 Announcement in Chinese_final)。

有关本次活动的任何问题请联系：office@scbahome.org
Seattle Chinese Biomedical Association
Society of Chinese Bioscientists in America – Seattle Chapter

Introduction

The SCBA Summer Research Program (SCBA_SRP) is an intensive, 8-week, unpaid internship for high school students. It is designed to provide research experience and mentorship for high school students interested in biomedical research. The Program offers a great opportunity for students to try something new or take their experience to the next level. Under the guidance of a faculty and/or a research staff mentor, interns will participate in the ongoing research of a laboratory and present their findings either within the research group or at the SCBA regular academic seminars.

The program runs from the first week (Jun. 20^th) of the summer quarter for 8 weeks. Students must be able to commit to this entire period in order to participate.

Eligibility Requirements:

1) High school students entering the summer after 9^th grade but before 12^th grade (seniors are not eligible).

2) Strong scientific interest and academic background.

3) Available for the entire eight-week program in a research laboratory located in Seattle.

Application Procedure:

1) Fill out the online form on the website through this link, which includes a number of short-response questions or essays.

2) Provide contact information and request two reference letters to be sent to SCBA

3) Upload a PDF of your recent school transcript.

4) Upload a PDF of your resume.

5) Attend a Zoom interview (for the finalists) with the Selection Committee.

All application components and two letters of recommendation are required.

Interns are responsible for securing their own housing, transportation, and other personal expenses during their internship. Application is due on May 10 this year.

All the qualified applications will be reviewed and judged by SCBA summer internship subcommittee. The acceptance entering the internship program will be announced in May each year.

For any questions, please contact scba.internship@gmail.com.

APPLY HERE!

经过几次酝酿和讨论，并听取了协会荣誉理事、美洲华人生物科学学会现任主席刘善虑的介绍和邀约，协会理事会于二零二二年三月十二日无异议表决通过，西雅图华人生物医学协会决定加入美洲华人生物科学学会，成为其在美国西北地区的一个分会，以西雅图华人生物医学协会暨美洲华人生物科学学会西雅图分会冠名。

美洲华人生物科学学会是成立于一九八四年、拥有数千会员的专业学会，目前在北美与全球拥有四十多个以专业横向建制和以地方纵向建制的分会。加入美洲华人生物科学学会这个大家庭，是基于双方拥有一致的专业方向与相似的建会宗旨；加入美洲华人生物科学学会这个大家庭，西雅图华人生物医学协会将得以在更大的平台上拓展和加强与更多华人学者的联系与交流。

加入美洲华人生物科学学会之后，西雅图华人生物医学协会将延续原有的运作和管理模式不变。在大西雅图地区的美洲华人生物科学学会会员，将被视为西雅图华人生物医学协会会员且享受相同待遇。

特此公告。

西雅图华人生物医学协会暨
美洲华人生物科学学会西雅图分会
理事会

二零二二年三月十三日

Dear SCBA members and friends,

Please mark your calendar and attend a SCBA academic seminar in the evening on March 26th, 2022.

When:

Saturday March 26, 2022; starting from 6PM, (GMT-8:00) Pacific Time, US

Sunday March 27, 2021; starting from 9AM, (GMT+8:00) Beijing/Shanghai, PRC

Where：

Zoom Seminar Meeting ID: 930 8331 6289 Password: SCBA

Join Zoom Meeting： https://zoom.us/j/93083316289

1. Molecular Diagnosis of Lung Cancer- Guide Targeted and Immune Therapies

By Jinjuan Yao, MD, PhD, Assistant Attending at the Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center

2. Precise Diagnosis of Histological Type of Lung Cancer

By Haodong Xu, MD, PhD, Professor at the Department of Laboratory Medicine and Pathology，University of Washington Medical Center

Please see the attached flyer for details in Chinese version.

Best regards,

Seattle Chinese Biomedical Association (SCBA)

Home

西雅图华人生物医学协会将于12月18日举行2021年学术年会暨会员大会。

学术年会以“神经科学”为主题，邀请四位享有盛誉的知名学者发表演讲，分享他们在各自领域的研究成果。学术讲座对公众开放，无须登记注册，欢迎感兴趣的各方面人士积极参与。四位特邀演讲人与演讲题目是：

• 阿伦脑科学研究所执行副总裁和所长曾红葵教授：脑细胞类型多样性的研究；
• 福瑞德· 哈金森癌症研究中心白继红副教授：对于神经突触的暂时性胞内体的研究；
• 浙江大学病理中心主任章京教授：解密神经退行性疾病的一把新钥匙：胞外囊泡所含的生物标记物；
• 清华大学药学院和麦戈文脑科学研究院肖百龙教授：机械敏感性离子通道Piezo的力量感知。

学术年会中将会宣布2022 SCBA-Sino Biological Young Investigator Award 和 SCBA Summer Intern Program for High School Students.

学术年会之后将是会员大会，包括例行协会年度工作报告等事宜。因为疫情，协会决定免收2021-2022年度会员费。请各位有意加入或者继续保留协会会员身份的同仁通过以下链接进行注册：http://scbahome.org/membership，协会将向注册会员寄发有关材料。

今年的学术年会及会员大会都通过网络会议形式举行：
时间：2021年12月18日（星期六）下午三点点到七点（美国西部时间）
网络会议地址：Zoom 会议号码：987 2120 1616；密码：scba2021

注意事项：
1. 欲了解学术年会详情者，请见：

2021-Conference

2. 希望成为注册会员者（免收会费），
请通过以下链接注册：

Membership

Dear SCBA Members and Friends:

Please mark your Calendar. Our SCBA All-Members Annual Meeting will take place on Saturday, Dec. 18th, 2021 from 3:00 PM to 7:00 PM through Zoom.

This year, we have lined up 4 outstanding speakers (2 from Seattle/USA and 2 from China) in the basic and clinical research field of neuroscience:

Hongkui Zeng, Ph.D, Executive Vice President and Director of Allen Institute for Brain Science. “Understanding Brain Cell Type Diversity.”

Jihong Bai, Ph.D, Associate Professor, Basic Sciences Division, Fred Hutchinson Cancer Research Center. “Transient Endosomes at Synapses.”

Jing Zhang, MD, PhD, Director of Pathology Center, Zhejiang University and Director of National Human Brain Bank for Health and Disease. “Decoding Neurodegenerative Diseases with Blood Biomarkers Contained in Extracellular Vesicles.”

Bailong Xiao, PhD, Professor, School of Pharmaceutical Sciences, Tsinghua-Peking Joint Center for Life Sciences, IDG/McGovern Brain Research Institute, Tsinghua University. “Feeling force with the mechanosensitive Piezo channels.”

Please note: Meeting scientific programs are open and free to all attendees. Registered SCBA members have the rights to vote and to be elected plus free meeting dinner and free or reduced summer BBQ for future in-person events. The 2021~2022 membership fee is waived due to COVID-19 pandemic. Except for permanent members, for all old and new members, please register either online http://scbahome.org/membership  or through SCBA email office@scbahome.org to become an active SCBA member.

More detailed meeting information (meeting agenda and zoom login info etc.) will come soon.

Best Regards,
SCBA office

二零二一年九月份学术活动通知

Academic Seminar in September 2021 Co-organized by SCBA and CIE (Chinese Institute of Engineers)
时间：2021 年9 月25 日（星期六）美国太平洋时间傍晚7 点到9 点
（北京时间9 月26 日上午10 点）
地点：Zoom 网络会议 会议室: 933 5639 9757 密码: SCBACIE

1. 美容手术与抗衰老
Cosmetic Surgery and Anti-Aging

蒲力群 博士 (Lee Li-Qun Pu, MD, PhD, FACS, FICS, Professor of Clinical Surgery, Director of Reconstructive Microsurgery, University of California Davis School of Medicine, Sacramento, California)

虽然人类抗衰老是一个非常复杂的议题，但是美容手术（包括外貌的美容与身体的整形）仍旧成为很多不同年龄段希望永葆青春容颜的人们的一个备选方案。身体的整形包括面部整形、胸部整形及其它更复杂的身体部位轮廓整形（包括生育后女性生殖器官的活力回复）。目前美容与整形大都采用侵入性较小的手术，包括肉毒杆菌填充剂注射、埋线提升和激光皮肤磨削术等。对于以上的美容整形手术，选择美容整形外科医生最为重要。本次讲座，浦博士将为大家讲解美容整形的最新进展以及如何选择合格的美容整形外科医生。

2. 让生命暂停：深低温生命保存中的前沿技术的研发与探索
Pause Life: Development of Novel Technology for Biopreservation at Deep Low Temperature
任莘 博士 (Shen Ren, Ph.D., Postdoctoral Scholar, Center for Cryo-Biomedical Engineering and Artificial Organs, University of Washington)

生命体的深低温保存是一种将生物样本置于负196 摄氏度的液氮环境中长期贮存的技术，以使生物体的新陈代谢及其他生命活动暂停。这一技术在生物医药的基础研究及临床实践中均有着广泛的应用。然而长久以来，技术的突破始终被局限在小体积的生物材料。针对大体积（如组织、器官等）生物样本的保存，除了降温过程中的技术难点，复温过程亦存在一系列重大挑战。复温技术上的革新将成为大样品冻存的关键突破，为组织和器官的移植以及药品与疫苗的研发，提供崭新的方向。本次讲座中，任博士将结合所在实验中心近期研究开发的新型高速均匀自动复温系统，综合探讨大样本生物样品低温保存的技术难点和潜在的解决方案。

有关本次活动的任何问题请与主办方联系（office@scbahome.org；CIE_news@ciesea.org ）

二零二一年八月份学术活动通知
Industry Seminar in August 2021

时间：2021 年8月7 日（星期六）美国太平洋时间傍晚5点到7点半
（北京时间8月8日上午8点）
地点：网络会议 会议室: 920 7678 9844 密码: SCBA

1. 回顾 – 加速并提高双特异抗体的研发成功率
Accelerate and Boost R&D Success of Bispecific Antibodies: a Reflection
郑松茂 博士 (Songmao Zheng, PhD，Associate Vice President of Research and Development at Adagene Inc.)

在本讲座中，郑博士将分享开发双特异性抗体 (BsAbs) 的一些研究案例和经验，针对 1) 在同一细胞上表达的两个膜结合靶标；2) 两个可溶性循环靶标；以及 3) CD3 T细胞重定向抗体。这些采用不同构建方式的大分子药物在过去几年中引起了生物技术和制药公司的极大兴趣并取得很大进展，郑博士将特别阐述这些药物的药代动力学、靶点结合特征和药效学。

2. 细胞疗法在肿瘤免疫治疗中的应用
Overview of cell therapy for Immuno-oncology application
曹澜 博士（Lan Cao, PhD, VP, Oncology Cell Therapy Innovation, Takeda Pharmaceuticals)

自FDA批准Kymriah和Yescarta以来，细胞疗法已引起生物制药公司以及风险投资人的极大兴趣，尤其是针对肿瘤的治疗。但是该领域仍然存在一些重大挑战和空白。例如，如何开发针对血液系统恶性肿瘤更好的产品？治疗实体瘤的突破性产品将会是什么？同种异体细胞产品会取代来自自身的细胞吗？未来最有治疗前景的免疫细胞类型是什么？其规模化生产制造前景如何？在本次讲座中，曹澜博士将就这些话题分享他的观点。

3. 抗体偶联药物开发的关键点
Key Points of Antibody-Drug Conjugate (ADC) Development
王雷，普方生物制药（苏州）有限公司 研发高级总监

ADC药物由三部分组成：抗体、连接子和化合物。由于成分组合复杂多变，每一部分的改变都会对疗效、安全性造成巨大影响。另外，对机制的见解和工艺方面要求非常高，是一条宽进严出的赛道。因此将ADC药物从开发至成功上市，需要对ADC的每个部分进行深入研究、开发，并对其整体进行全面分析。目前全球大约已上市13款ADC药物，有80款候选药物正处于临床阶段，超过50款ADC药物由于缺乏疗效或存在系统性毒性终止了临床试验。因此，ADC药物的开发依然存在门槛高、风险高等特性。本次讲座将回溯ADC的发展历程、当前的ADC进展、讨论ADC开发时需要关注的关键组成部分及如何整体把握ADC等。

有关本次活动的任何问题请与安杰博士联系（office@scbahome.org）

时间：2021 年4 月24 日（星期六）晚上7 点到9 点
地点：Zoom Seminar Meeting ID: 924 5765 3003 Password: SCBA

1. 运用21世纪新方法解决老问题——衰老与神经性退行性疾病中的创新研究
Tackling an Age-old Question with 21st Century Toolbox: New Approaches to Study Aging and Age-related Neurodegenerative Disorders

杨向东 博士 (Xiangdong Yang, M.D., Ph.D., Professor and Terry Semel Chair in Alzheimer’s Disease Research and Treatment at Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA)
随着全球人口老龄化到达史无前例的水平，阿尔兹海默症等神经性退行性疾病成为蔓延世界的另一类“瘟疫”。本次讲座，我将以本实验室近期研究开发的新型遗传学模型、系统生物学研究方法和神经生物学研究技术，综合探讨包括阿尔兹海默症和亨廷顿舞蹈症在内的，与老龄化有关的主要神经性退行性疾病的病理机制和可能的临床解决方案。迄今，我们的研究已为找寻新的治疗靶点、开发新的临床治疗方案以及开展临床测试等提供了良好的基础。同时，我也将讨论如何基于新的生物学（非年龄性）标识，来准确测量不同哺乳动物的生物学年龄。基于衰老本身的生物学机制的研究，可能为我们研究延缓和恢复年龄相关性大脑系统疾病，如阿尔兹海默症等，提供崭新的方向。

2. 儿童神经发育障碍性疾病的遗传学研究和进展
The genetics of neurodevelopmental disorders

王天云 博士（Tianyun Wang, Ph.D., Senior Postdoctoral Fellow, Department of Genome Sciences, School of Medicine, UW)
儿童神经发育障碍性疾病是一组具有高度临床和遗传异质性的复杂疾病，主要包括孤独症谱系障碍、发育迟缓/智力障碍、癫痫以及注意力缺陷多动障碍等，其发病率高，并能严重影响婴幼儿发育、运动和社会适应等，给家庭和社会造成了严重的负担。目前其发病机制尚不完全清楚，但研究发现遗传因素在其中有重要作用。近年来，我们通过国际间合作的大规模测序研究，成功地鉴定了上百个相关的风险基因以及染色体拷贝数变异等致病位点，并对其中部分基因进行了进一步的致病机理研究，为疾病的认识和诊疗提供了新的思路。

有关本次活动的任何问题请与安杰博士联系（office@scbahome.org）。